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Lovastatin and Cholesterol

    

  

    LovastatinWikipedia(1) is a natural compound found in food
 such as oyster mushrooms (Pleurotus Ostreatus)Wikipedia(2)
and red yeast rice. The oyster mushroom was cultivated
in Germany as a subsistence measure during the first
World War.The mushroom has a broad, fan or oyster-
 -shaped cap spanning 5 to 25 cm.The red yest rice is a
 bright reddish purple fermented rice, which acquires its
 colour from being cultivated with the mold "Monascus
purpureus"





  The standard oyster mushroom can grow in many places, but some other related species, such as the branched oyster mushroom, grow only on trees.The red yest rice is a bright reddish purple fermented rice


    The original uses of lovastatin is for the treatment of
dyslipidemia (abnormal amount of lipids in the blood)Wikipedia(3) and the prevention of coronary heart disease.

Lovastatin belongs to the group of statins ( a class
of drugs used to lower cholesterol levels by inhibiting the
enzyme HMG-CoA reductase).

   It's potential in use for lowering bad Cholesterol was
clinically tested early 1980s and subsequently approved
by the US Food and Drug Administration (FDA) in 1987.


Brand Names; Oral administrationWikipedia(2)

-Mevacor®
-Altocor ®
-Altoprev ®
-Advicor ® (Vitamin B3 and Lovastatin)

Dosage; (Two references)

-The usual recommended starting dose is 20 mg once a day given with the evening meal. The recommended dosing range of lovastatin is 10-80 mg/day in single or two divided doses; the maximum recommended dose is 80 mg/day.RxList(1)


-The dose range for lovastatin is 10-80 mg daily given preferably in the evening when it may be most effective. The usual starting dose is 20 mg once daily, and the maximum dose is 80 mg daily. Blood cholesterol determinations are performed at regular intervals during treatment so that adjustments in dosage can be made.MedicineNet






Main Side effects; RxList(2),Everyday Health,Wikipedia(1)


Swelling of the face, throat, tongue, lips, eyes, hands, feet,
ankles, or lower legs.

Fever,mild nausea, upper stomach pain, joint pain,back pain,
chest pain,mild muscle pain,abdominal pain, tenderness, loss
of appetite,blurred vision,dark urine, clay-colored stools,gas
diarrhoea, headache,dizziness.

Jaundice (yellowing of the skin or eyes)

Lack of energy or weakness

Hoarseness

Flu-like Symptoms

Hives

Constipation

Sleep problems (insomnia)

Moderate risk in cognitive function Time Health(Confusion, memory
problems) and increase in blood sugar levels and Type 2
diabetes.

Lovastatin can rarely cause; RxList (2) , Wikipedia(1)

 -hepatotoxicity (liver damage)

 -Dermatomyositis ( inflammation of the muscles and the skin)

 -Rhabdomyolysis (damage skeletal muscle issue)

 -Myopaty(Muscle disease)

 Obs; Older adults may be more sensitive to the side effects of this drug,especially muscle problems.RxList (3)

*There may be other side effects not mentioned here.



Contraindications;Wikipedia(1)

-Allergic reaction:Symptoms of hypersensitivity,adverse drug reaction.

-Pregnancy: Fetal abnormalities risk.
 
-Breast feeding:Due to its potential to disrupt infant lipid-meta
bolism lovastatin should not be taken while breastfeeding.

-Liver disease: Patients with liver disease should not take
lovastatin.
 
- (HIV) Infected patients taking protease inhibitor (PI)
based highly active antiretroviral therapy (HAART). Pharmacology Weekly
   
   *Avoid drinking alcoholic beverages while taking lovastatin.

  **Avoid drinking grapefruit juice while taking lovastatin.Drugsdb 

***Dosage increases above 20 mg/day to patients with severe renal insufficiency(creatinine clearance < 30 mL/min) need be carefully considered and cautiously implemented.DrugLib

 Visit, if possible,the website of the organism regulatory of body drugs of your country and talk to your doctor/pharmacist too.You need to consider always the prevention through lifestyle changes first, trying drug treatment only if your doctor recommend it. As with all therapies; the decision to use Lovastatin or other statins for primary or secondary prevention must include careful consideration of the risks and benefits, side effects and cost.

Call FDA at 1-800-FDA-1088 (MedWatch) to report problems about
any medication.

U.S Emergency Doctors: Dial 911


 

References;

- Wikipedia (The Free Encyclopedia)

(1)http://en.wikipedia.org/wiki/Lovastatin

(2)www.http://en.wikipedia.org/wiki/Pleurotus_ostreatus

(3)www.http://en.wikipedia.org/wiki/Dyslipidemia


-MedicineNet

http://www.medicinenet.com/lovastatin/page2


-RxList (The Internet Drug Index)



(1) http://www.rxlist.com/mevacor-drug/indications-dosage.htm

(2) http://www.rxlist.com/mevacor-side-effects-drug-center.htm

(3)http://www.rxlist.com/mevacor-drug/consumer-side-effects-
precautions.htm

-Everyday Health

http://www.everydayhealth.com/drugs/lovastatin


-Time Health

http://healthland.time.com/2012/02/29/fda-warns-statin-users-of-
memory-loss-and-diabetes-risks/

-Pharmacology Weekly articles.

http://www.pharmacologyweekly.com/articles/lovastatin-mevacor
-protease-inhibitors-PI-HIV-AIDS-antiretrovirals-lipids-cholesterol


-Drugsdb (Drug Information & Side effects Database)

http://www.drugsdb.com/rx/lovastatin/lovastatin-and-grapefruit/

-DrugLib (Drug Information Portal)



http://www.druglib.com/druginfo/advicor/indications_dosage/



 

Important websites about lovastatin:




U.S Food and Drug Administration-(FDA)

National Institutes of Health-(NIH)

Wikipedia

Monthly Prescribing Reference-(MPR)

Medline

emedicinehealth

U.S. Pharmacopeial Convention

Pharmacopeia Online

The Internet Drug Index (RxList)

Science Based-Medicine





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Author: Friia,Luiz  Contact:lovastatin@lovastatin.org
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